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. 2017 Apr 6;7:714. doi: 10.1038/s41598-017-00671-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TIMP-1 deficient mice are not protected from hepatic carcinogenesis. Liver carcinogenesis was induced via juvenile DEN injection. (a) No differences between TIMP-1 wt and ko could be observed in tumor number or size. (b) TIMP-1 wt and ko show the same liverweight/bodyweight ratio. (c) ALT level were not induced following DEN treatment and did not differ between TIMP-1 wt and TIMP-1 ko. (d) Representative pictures of excised livers and (e) in vivo MRI images show equal tumor load of livers. Bar columns represent mean ± standard error of the mean. (n = 16–22).