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. 2017 May 8;12:3547–3559. doi: 10.2147/IJN.S127663

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© 2017 Orlando et al. This work is published and licensed by Dove Medical Press Limited

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Normalized averaged SR for experiments with MSNPs of different sizes.

Notes: Each point represents a segment time of 30 minutes, for which averaged data were normalized to mean control value; the arrow indicates MSNP administration. (A) MSNPs of 30 nm increased mean value of SR versus control: in control and at the end of treatment, the averaged data normalized for excitatory (inhibitory) neurons were 1.14±0.03 (1.1±0.06) and 2.21±0.2 (1.8±0.44) Hz, respectively; no significant difference was detected between different time points (P>0.05). (B) MSNPs of 250 nm did not affect the neuronal network. Values presented as mean ± standard error of mean obtained from three replicates (n=3).

Abbreviations: MSNPs, mesoporous silica nanoparticles; SR, spike rate.