Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 4;7:640. doi: 10.1038/s41598-017-00699-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Tolbutamide effects on membrane potential and conductance with perforated patch recordings. (A) A representative dSCN neurone showing the effects of tolbutamide on spontaneous firing (left panel) and membrane potential (right panel) after the addition of TTX to block action potentials. Note the weak depolarisation by tolbutamide. Daytime recordings (ZT 7). (B) A representative dSCN neurone showing the reversible effects of tolbutamide on the membrane current (top panels) and the I-V relations (bottom panel). Note the small inward current induced by tolbutamide at a holding potential of −52 mV (marked by arrowhead). Nighttime recordings (ZT 13). (C) Summary of tolbutamide-induced depolarisation (left panel) and tolbutamide-sensitive conductance (right panel). Baseline resting potential: dSCN (−56 ± 1 mV; n = 39), vSCN (−56 ± 1 mV; n = 39). Baseline resting conductance: dSCN (0.38 ± 0.05 nS; n = 17), vSCN (0.31 ± 0.04 nS; n = 17). Dotted lines are zero current levels.