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. 2017 Apr 5;7:649. doi: 10.1038/s41598-017-00640-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of trafficking motifs in the C-ter of TWIK2. (A) Sequence of human, rat and mouse TWIK2 C-ter. The trafficking motifs are shown in bold. Overview of the set of generated mutants, in which underlined amino acids were replaced by an alanine residue. (B) Current amplitudes at +50 mV of the corresponding rat TWIK2 mutants recorded in Xenopus oocytes (number of recorded oocytes) expressed as mean current amplitude ± sem. Mutant rat TWIK2HA channels were transfected into MDCK cells and stained with HA antibody. % cell surface expression corresponds to the percentage of transfected cells showing a clear expression of TWIK2 at the plasma membrane. (C) Representative images of MDCK cells expressing the different TWIK2 mutations shown in (B) and TREK1. Scale bar: 10 µm.