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. 2017 Apr 4;7:619. doi: 10.1038/s41598-017-00682-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EGCG suppresses the increased 3R-tau expression in Ts65Dn mice. Ts65Dn or control mice were treated with EGCG from mating to adulthood. The 3R-tau, 4R-tau and total tau in the forebrains from 5 month old mice were analyzed by Western blots (A). The level of Dyrk1A (B), 3R-tau (C), 4R-tau (D) and ratio of 3R-tau/4R-tau (E) are presented as mean ± S.D. (n = 3–5) and analyzed by two way ANOVA followed post-hot test. *p < 0.05; **p < 0.01; ***p < 0.001.