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. 2017 Apr 4;7:638. doi: 10.1038/s41598-017-00630-w

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© The Author(s) 2017

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Fat mobilization is mediated by HOSL-1 during cold stress. (a) A representative image of lipid droplets using Oil Red O staining. Lipid hydrolysis was significantly inhibited in worms subjected to hosl-1(RNAi). *P < 0.05. Scale bar, 150 μm. (b and c) The expression of Phosl-1::gfp (b) or the mRNA levels of hosl-1 (c) were up-regulated at 12 h after cold exposure. The mutation in kin-1(ok338) inhibited the expression of hosl-1. The right panel represents relative GFP fluorescence intensity (b). *P < 0.05. Scale bar, 100 μm. (d) hosl-1(RNAi) reduced the survival rate of worms at 4 °C. However, hosl-1 RNAi did not enhance cold susceptibility of kin-1(ok338) worms. P < 0.001 relative to WT with empty vector.