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(Left) The regulatory network for pluripotency derived by Dunn and co-workers in ref. 34. (Right) The reduced network that we study here in which Lif is taken as a noisy input and Oct4 is taken as the target. Since CH and PD cannot be reached from Lif via a walk on this network, we can exclude these nodes, along with Tcf3 and ERK, from our analysis. Edges that participate in feedback loops in the network are shown in red.
