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. 2017 Apr 4;7:633. doi: 10.1038/s41598-017-00685-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Association of various drugs with lipoproteins. (A) Serum lipoprotein fractions from wild-type mice obtained 2 h after oral drug administration were identified according to the concentrations of cholesterol and triglycerides, and the presence of apoB-100, apoAI, and albumin. The total amount of cholesterol and triglycerides in the fractions was considered to be 100%. (B–F) In vivo analysis of drug association with lipoproteins. (B) Clarithromycin; (C) labetalol; (D) sulfadiazine; (E) ticlopidine; and (F) amiodarone. (G) The left panel shows the BDDCS classification of drugs into four types. The right panel shows the extent of drug-lipoprotein association according to BDDCS. **p < 0.01.