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. 2017 Apr 4;7:633. doi: 10.1038/s41598-017-00685-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clarification of VLDL/LDL-mediated drug transport in vivo. (A) Comparison of the association of cholesterol with lipoproteins between wild-type (WT) and LDLR-mutant (LDLR-MT) mice. (B) Serum cholesterol concentrations in WT and LDLR-MT mice. (C) Serum clopidogrel concentrations in WT and LDLR-MT mice. (D) Clopidogrel concentrations in lipoprotein fractions at 4 h after clopidogrel administration. Bars represent the mean ± s.e.m. *p < 0.05. **p < 0.01.