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. 2017 Apr 4;7:633. doi: 10.1038/s41598-017-00685-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of LDLR overexpression on VLDL/LDL-mediated drug transport in vivo. (A) LDLR-mutant (LDLR-MT) mice were infected with LDLR-expressing adenovirus to generate LDLR-rescued mice (LDLR-MT+Ad-LDLR). GFP-expressing adenovirus was used as a control. Three days after the infection, overexpression of LDLR was confirmed by western blotting. (B) Association of cholesterol with lipoproteins in LDLR-MT and LDLR-MT+Ad-LDLR mice. (C) Effect of adenovirus-mediated LDLR-overexpression (Ad-LDLR) on serum cholesterol concentration in LDLR-MT mice. (D) Serum clopidogrel concentration in LDLR-MT and LDLR-MT+Ad-LDLR mice. (E) Effect of LDLR rescue on the hepatic concentration of clopidogrel and its metabolites at 4 h after clopidogrel administration. Bars represent the mean ± s.e.m. *p < 0.05, **p < 0.01.