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. 2017 Mar 28;7:472. doi: 10.1038/s41598-017-00601-1

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effects of electric stimulation at the ear and electro-acupuncture at ST36–ST37 on the counts of COX-2, GFAP, S100-B, RAGE, mGluR3, MCP-1, and CCR2 immunoreactive cells in kainic acid (KA)-induced epileptic seizure rats. The CA1, CA2, CA3, and hilus regions of the hippocampus (A). The counts of COX-2, GFAP, and S100-B immunoreactive cells were higher in the KA group (KA) and sham group (Sham) than in the normal group (Normal), whereas these counts were decreased in the auricular group (Ear) and Zusanli group (Zusanli). The counts of RAGE, mGluR3, MCP-1, and CCR2 immunoreactive cells were similar among the normal, KA, sham, and auricular groups (B). Immunoreactive cell (arrowhead); B image is 400× in the CA1 region; n = 6.