Table 1.
Validation of miR-SNPs for the BMD association analysis.
| TARGET GENE | miRNA | SNP | MAFB | Association with BMD |
|---|---|---|---|---|
| ESR1 | miR-106b | rs72631827 | Monomorphic | |
| miR-130b | rs72631822 | Monomorphic | ||
| miR-148b | rs74878365 | Monomorphic | ||
| miR-18a | rs41275866 | Monomorphic | ||
| miR-222 | rs72631825 | Monomorphic | ||
| miR-373 | rs80338016 | Monomorphic | ||
| miR-520c | rs7255628 | Monomorphic | ||
| miR-93 | rs72631824 | Monomorphic | ||
| miR-96 | rs41274239 | 0.0033 | MAF < 0.01 | |
| rs73159662 | 0.0058 | |||
| TGFB2 | miR-141 | rs34385807 | Monomorphic | |
| miR-149 | rs71428439 | Monomorphic | ||
| miR-182 | rs77586312 | Monomorphic | ||
| rs75953509 | Monomorphic | |||
| rs80041074 | 0.0033 | MAF < 0.01 | ||
| miR-199b | rs72631835 | Monomorphic | ||
| miR-193a | rs60406007 | Monomorphic | ||
| miR-200b | rs72563729 | Monomorphic | ||
| miR-33a | rs77809319 | Monomorphic | ||
| miR-431 | rs76090066 | 0.00083 | MAF < 0.01 | |
| rs128840′05 | Monomorphic | |||
| miR-590 | rs6971711 | Monomorphic | ||
| miR-7-1 | rs76662330 | Monomorphic | ||
| miR-7-2 | rs41276930 | 0.005 | MAF < 0.01 | |
| rs75737367 | Monomorphic | |||
| PTH1R | miR-339 | rs13232101 | Monomorphic | |
| rs72631820 | Monomorphic | |||
| rs72631831 | Monomorphic | |||
| RUNX2 | miR-122 | rs41292412 | 0.0033 | MAF < 0.01 |
| miR-154 | rs41286570 | 0.0004 | ||
| IL6R | miR-124-2 | rs72631829 | Monomorphic | |
| miR-124-3 | rs34059726 | Monomorphic | ||
| miR-125a | rs12975333 | Monomorphic | ||
| miR-140 | rs7205289 | Monomorphic | ||
| miR-320d-1 | rs74826059 | Monomorphic | ||
| miR-499 | rs3746444 | 0.21 | Not associated | |
| rs7267163 | 0.0025 | MAF < 0.01 | ||
| LRP5 | miR-27a | rs11671784 | 0.0162 | Not associated |
| IL6 | miR-146a | rs2910164 | 0.26 | Not associated |
| miR-146b | rs76149940 | Monomorphic | ||
| miR-202 | rs12355840 | Monomorphic | ||
| miR-365-2 | rs35143473 | Monomorphic | ||
| VDR | miR-10a | rs72631828 | Monomorphic | |
| miR-223 | rs34952329 | Monomorphic | ||
| CYP24A1 | miR-30b | rs111424617 | Monomorphic | |
| miR-30e | rs112439044 | Monomorphic | ||
| miR-183 | rs72631833 | Monomorphic | ||
| rs41281222 | Monomorphic | |||
| miR-101-2 | rs78851134 | 0.0004 | MAF < 0.01 | |
| Highly expressed in HObs | miR-1282 | rs11269 | Monomorphic | |
| miR-3679 | rs6430498 | 0.35 | Associated with FN BMD | |
| rs10175383 | Monomorphic | |||
| miR-4274 | rs12512664 | 0.47 | Associated with FN BMD |
MAFB; Minor allele frequency in BARCOS cohort; SNPs with MAF<0.01 were excluded for genotyping. In bold; Validated SNPs for genotyping in total OSTEOMED2 cohort.