Table 3.

Quasispecies diversity (genetic distance, dS, and dN) between the patients with coexisting HBsAg and anti-HBs and controls.

Region of variation (level)	Experimental group	Control group	P value
	(mean ± SE) (n = 6)	(mean ± SE) (n = 6)
Full length (nt)	0.0076 ± 0.0021	0.0037 ± 0.0005	0.122
PreS/S
Large HBsAg (nt)	0.0088 ± 0.0021	0.003 ± 0.0004	0.04
Large HBsAg (aa)	0.0183 ± 0.0044	0.0057 ± 0.001	0.034
Middle HBsAg (nt)	0.0087 ± 0.0019	0.003 ± 0.0004	0.033
Middle HBsAg (aa)	0.0187 ± 0.0044	0.0061 ± 0.0014	0.036
HBsAg (nt)	0.009 ± 0.002	0.0039 ± 0.0012	0.05
HBsAg (aa)	0.0196 ± 0.0048	0.0069 ± 0.0016	0.045
X
HBxAg (nt)	0.0068 ± 0.002	0.0051 ± 0.0011	0.47
HBxAg (aa)	0.0126 ± 0.0039	0.0095 ± 0.0013	0.481
C/CP
HBcAg (nt)	0.009 ± 0.0032	0.0048 ± 0.0008	0.235
HBcAg (aa)	0.0152 ± 0.0065	0.0101 ± 0.0023	0.48
Core promoter (nt)	0.0069 ± 0.0028	0.0063 ± 0.0017	0.876
P
Polymerase (nt)	0.0072 ± 0.0018	0.0034 ± 0.0004	0.091
Polymerase (aa)	0.0117 ± 0.0026	0.0063 ± 0.0008	0.097
RT region (nt)	0.0079 ± 0.002	0.0032 ± 0.0005	0.071
RT region (aa)	0.0114 ± 0.0025	0.0059 ± 0.0009	0.066
PreS/S
Large HBsAg (dS)	0.0089 ± 0.0021	0.0042 ± 0.001	0.068
Large HBsAg (dN)	0.0085 ± 0.0021	0.0025 ± 0.0004	0.037
Middle HBsAg (dS)	0.0073 ± 0.0014	0.0038 ± 0.0007	0.05
Middle HBsAg (dN)	0.0088 ± 0.0022	0.0027 ± 0.0006	0.043
HBsAg (dS)	0.0085 ± 0.003	0.0063 ± 0.0034	0.633
HBsAg (dN)	0.009 ± 0.0023	0.0031 ± 0.0007	0.049
X
HBxAg (dS)	0.0099 ± 0.0031	0.0064 ± 0.0023	0.39
HBxAg (dN)	0.0058 ± 0.0018	0.0044 ± 0.0007	0.512
C
HBcAg (dS)	0.0149 ± 0.0052	0.0051 ± 0.0019	0.127
HBcAg (dN)	0.007 ± 0.0031	0.0045 ± 0.001	0.469
P
Polymerase (dS)	0.0129 ± 0.0037	0.0052 ± 0.0009	0.094
Polymerase (dN)	0.0053 ± 0.0012	0.0028 ± 0.0004	0.093
RT region (dS)	0.0163 ± 0.005	0.0051 ± 0.0016	0.079
RT region (dN)	0.0052 ± 0.0012	0.0026 ± 0.0004	0.08