Table 4.

Codons in the HBV genes that were under positive selection.

Gene	Codon	Wild type amino acid (B, C, I genotype)	Posterior probability	Omega (±s.e.m.)	Subjects and clones at each sited		p valuee
					Experimental group 91(6)	Control group 87(6)
LHBsAg	300	T, I, I a,b,c	0.936	1.633 ± 0.479	29(3)	15(1)	0.037
HBxAg	36	A, P, D	0.999	3.753 ± 0.823	62(5)	59(4)	1.000
	44	V, A, A c	0.91	3.430 ± 1.074	14(2)	12(1)	0.930
	127	V, I, I a,b	0.979	3.688 ± 0.902	45(3)	8(2)	1.149E-08
	130	K a,b	1	3.755 ± 0.820	78(5)	45(5)	2.100E-06
	131	V a,b	1	3.756 ± 0.819	78(5)	30(4)	7.854E-12
Pol	136	Y, H, Q	0.908	2.381 ± 0.544	33(3)	14(1)	0.004
	237	Q, S, S	0.925	2.411 ± 0.509	30(3)	14(1)	0.015
	251	P, T, T	0.927	2.414 ± 0.505	25(2)	31(2)	0.312
	480	N, D, D	0.914	2.392 ± 0.531	4(1)	15(1)	0.005
	613	Q, L, Q	0.902	2.370 ± 0.563	49(3)	15(2)	8.179E-07
	615	I, L, I	0.936	2.429 ± 0.479	14(1)	29(3)	0.009
	713	Q, R, Q	0.933	2.424 ± 0.489	36(3)	30(2)	0.585
	803	R, H, H a	0.992	2.525 ± 0.278	29(4)	49(4)	0.002
	841	R, K, R	1	2.538 ± 0.235	53(4)	39(5)	0.101

^aHLA I T cell epitopes, ^bHLA II T cell epitopes, ^cB cell epitopes.

^dThe number of clones with positive selection (the number of affected patients).

^eThe number of clones with positive selection in HBsAg+/anti-HBs + group vs HBsAg+/anti-HBs- group, chi-square testing.