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. 2017 Feb 8;6(2):111–120. doi: 10.1530/EC-16-0078

Table 2.

The monthly serum variation in total 25(OH)D, directly measured free 25(OH)D, calculated free 25(OH)D, bioavailable 25(OH)D, 1,25(OH)2D and DBP.

Month of the year Total 25(OH)D (nmol/L) Directly measured free 25(OH)D (pmol/L) Calculated free 25(OH)D (pmol/L) Bio-available 25(OH)D (nmol/L) 1,25(OH)2D (pmol/L) DBP (mg/L)
January 48.4 ± 17.4 9.4 ± 2.4 15.4 ± 7.6 5.8 ± 3.0 115.4 ± 42.1 248.7 ± 78.9
February 47.4 ± 20.7 9.1 ± 2.7 14.0 ± 5.2 5.2 ± 1.9 123.2 ± 43.5 249.1 ± 62.2
March 48.0 ± 21.0 8.8 ± 2.7 15.2 ± 6.3 5.1 ± 2.7 107.0 ± 31.2 243.0 ± 91.4
April 50.3 ± 20.0 8.5 ± 2.4 15.7 ± 5.6 5.8 ± 2.1 104.0 ± 35.5 252.0 ± 67.0
May 53.8 ± 17.1 9.2 ± 2.4 15.5 ± 4.9 6.0 ± 2.0 111.2 ± 38.6 263.4 ± 76.8
June 72.6 ± 26.7 11.8 ± 3.6 22.7 ± 11.1 8.5 ± 4.1 119.4 ± 39.3 251.0 ± 72.0
July 81.9 ± 26.2 15.1 ± 4.8 26.4 ± 12.6 10.0 ± 5.2 129.0 ± 46.3 253.3 ± 87.3
August 80.4 ± 29.8 15.7 ± 4.4 25.7 ± 10.3 9.5 ± 3.6 113.7 ± 39.2 243.1 ± 75.5
September 67.4 ± 22.7 14.2 ± 4.1 20.3 ± 9.1 7.4 ± 3.2 149.4 ± 73.4 260.5 ± 64.6
October 69.9 ± 24.1 12.3 ± 4.0 20.6 ± 8.4 8.0 ± 3.3 111.8 ± 35.3 264.9 ± 69.8
November 56.8 ± 18.3 10.0 ± 2.7 17.7 ± 8.6 6.7 ± 3.2 110.0 ± 40.8 254.2 ± 83.4
December 54.2 ± 22.2 10.3 ± 3.3 19.5 ± 18.1 7.4 ± 7.0 113.5 ± 40.0 260.7 ± 112.4
All months#
Mean ± s.d. 60.5 ± 25.4 11.1 ± 4.2 18.7 ± 10.0 7.0 ± 3.8 115.9 ± 42.4 253.9 ± 78.1
95% CI 18.0–116.0 5.3–22.2 6.3–42.5 2.0–16.8 37.5–218.7 104.0–400.0
#

Values are adjusted for the fact that more subjects were included during the summer months.

1,25(OH)2D, 1,25-dihydroxy vitamin D; 25(OH)D, 25-hydroxy vitamin D; DBP, vitamin D-binding protein.