Table 4.

Mean percentage change between pre and post treatment values for each study for thyroid hormones and lipid parameters.

	TSH			Free thyroxine (FT4)			Free triiodothyronine (FT3)
	Before	Change	% Change	Before	Change	% Change	Before	Change	% Change
Caraccio et al. (23)
T4	–	–	–	11.6	2.8	24	4.8	0.3	6
Placebo	–	–	–	12.7	0.2	2	4.8	0.1	2
Monzani et al. (30)
T4	–	–	–	11.3	2.6	23	4.8	0.1	2
Placebo	–	–	–	10.9	−0.1	−1	4.6	0	0
Teixeira et al. (27)
T4	8.0	−5.88	−74	12.9	4.1	32	–	–	–
Placebo	8.4	−3.5	−42	12.9	2	16	–	–	–
Teixeira et al. (28)
T4	7.5	−4.6	−61	14.2	0	0	–	–	–
Placebo	8.01	−2.01	−25	14.2	1.2	8	–	–	–
Nagasaki et al. (32)
T4	7.32	−4.62	−63	14.5	1.5	10	5.06	0.08	2
Placebo	7.25	−0.24	−3	14	0.8	6	4.92	0.2	4

	Total cholesterol			LDL cholesterol			HDL cholesterol
	Before	Change	% Change	Before	Change	% Change	Before	Change	% Change
Caraccio et al. (23)
T4	5.5	−0.5	−9	3.6	−0.5	−14	1.5	−0.1	−7
Placebo	5.3	0	0	3.3	0.1	3	1.5	0	0
Monzani et al. (30)
T4	5.54	−0.58	−10	3.59	−0.51	−14	1.46	−0.05	−3
Placebo	5.51	0.17	3	3.55	0.1	3	1.47	0.02	1
Teixeira et al. (27)
T4	5.62	−0.52	−9	3.57	−0.51	−14	1.36	0.06	4
Placebo	4.83	0.41	8	2.94	0.41	14	1.43	−0.18	−13
Teixeira et al. (28)
T4	5.54	−0.58	−10	3.57	−0.48	−13	1.44	−0.08	−6
Placebo	4.87	0.19	4	3.05	0.38	12	1.43	−0.14	−10
Nagasaki et al. (32)
T4	5.59	−0.4	−7	3.58	−0.44	−12	1.41	0	0
Placebo	5.53	−0.2	−4	3.56	−0.2	−6	1.38	0.01	1

	Triglycerides			Apolipoprotein A			Apolipoprotein B
	Before	Change	% Change	Before	Change	% Change	Before	Change	% Change
Caraccio et al. (23)
T4	1.3	−0.1	−8	1.618	−0.128	−8	1.096	−0.083	−8
Placebo	1.4	−0.1	−7	1.584	0.031	2	1.053	0.018	2
Monzani et al. (30)
T4	1.06	−0.07	−7	1.66	−0.14	−8	1.07	−0.09	−8
Placebo	1.07	0.09	8	1.65	0.04	2	1.17	0.01	1
Teixeira et al. (27)
T4	1.21	−0.02	−2	1.376	0.04	3	0.966	0.059	6
Placebo	1.08	0.31	29	1.338	−0.034	−3	0.915	0.009	1
Teixeira et al. (28)
T4	1.16	−0.07	−6	1.403	0.093	7	0.948	−0.041	−4
Placebo	1.11	−0.1	−9	1.407	0.019	1	0.889	0.017	2
Nagasaki et al. (32)
T4	1.34	0.16	12	–	–	−	–	–	–
Placebo	1.37	0.01	1	–	–	–	–	–	–