Table 3. Results of multivariate and sensitivity analysis for receiving crystalloid and colloid fluid resuscitation episodes in 2014 compared to 2007.

Multivariate analysis (all fluid resuscitation episodes)a
Characteristic	OR (95%CI) for receiving crystalloid	P value	OR (95%CI) for receiving colloid	P value
Study
2007	1.00		1.00
2014	3.46 (2.59 to 4.64)	<0.001	0.28 (0.21 to 0.38)	<0.001
Sensitivity analysis (first fluid resuscitation episode only)b
Characteristic	OR(95%CI) for receiving crystalloid	P value	OR(95%CI) for receiving colloid	P value
Study
2007	1.00		1.00
2014	2.22 (1.33 to 3.70)	0.002	0.43 (0.26 to 0.72)	0.001

^a Results are generated from GEE model with patient ID as a cluster. Analysis include 1,979 episodes and 947 study participants as data were lost due to missing values which could not be included in the multivariate analysis. This number represents a loss of 7.0% of episodes and 7.0% of study participants.

^b Results are generated from GEE model with site/ICU ID as a cluster. Analysis include 848 first fluid episodes from 848 study participants as data were lost due to missing values which could not be included in the multivariate analysis. This number represents a loss of 16.7% of first fluid episodes/study participants.