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. 2017 May 12;13(5):e1006757. doi: 10.1371/journal.pgen.1006757

Fig 5. Reduced Brg1 protein levels impair organizer function.

Fig 5

X. laevis embryos were radially injected with 40ng of indicated MOs and fixed at early. Representative images of the predominant morphant expression patterns are shown by WMISH in vegetal (A, B, G-L) or dorsal (D, E, N, O) side views. The Organizer region is represented by nr3 (A-C), otx2 (D-F) and foxA4 (G-I). Inserts depict deep staining in bisected embryos for nr3 or blastopore lip staining for otx2. Non-organizer mesoderm is represented by the BMP target genes vent1 (K M) and vent2 (N-P). Inserts show side views for vent1 and vegetal views for vent2 (n = 2-4 independent experiments/gene).