Table II.
Correlation of clinicopathological characteristics and GINS2 expression in the early-stage cervical cancer patients.
| GINS2 | |||||
|---|---|---|---|---|---|
| Characteristics | Total (n=155) | Low expression | High expression | Chi-square test P-value | Fishers exact test P-value |
| Age (years) | 0.688 | 0.730 | |||
| ≤47 | 78 | 55 (35.5) | 23 (14.8) | ||
| >47 | 77 | 52 (33.5) | 25 (16.2) | ||
| FIGO stage | 0.571 | ||||
| Ia | 18 | 14 (9.0) | 4 (2.6) | ||
| Ib | 83 | 58 (37.4) | 25 (16.1) | ||
| IIa | 54 | 35 (22.6) | 19 (12.3) | ||
| Pelvic lymph node metastasis (PLNM) | <0.001 | <0.001 | |||
| No | 99 | 84 (54.2) | 15 (9.7) | ||
| Yes | 56 | 23 (14.8) | 33 (21.3) | ||
| Histological types | 0.440 | 0.667 | |||
| Squamous cell carcinoma | 149 | 102 (65.8) | 47 (30.3) | ||
| Adenocarcinoma | 6 | 5 (3.2) | 1 (0.7) | ||
| SCC-Ag (ng/ml) | <0.001 | <0.001 | |||
| ≤1.5 | 91 | 78 (50.3) | 13 (8.4) | ||
| >1.5 | 64 | 29 (18.7) | 35 (22.6) | ||
| Tumor size (cm) | 0.058 | 0.085 | |||
| ≤4 | 132 | 95 (61.3) | 37 (23.9) | ||
| >4 | 23 | 12 (7.7) | 11 (7.1) | ||
| Positive surgical margin | 0.304 | 0.374 | |||
| No | 149 | 104 (67.1) | 45 (29.0) | ||
| Yes | 6 | 3 (1.9) | 3 (1.9) | ||
| Deep stromal invasion | 0.021 | 0.025 | |||
| No | 49 | 40 (25.8) | 9 (5.8) | ||
| Yes | 106 | 67 (43.2) | 39 (25.2) | ||
| Positive parametrium | 0.898 | 1.000 | |||
| No | 149 | 103 (66.5) | 46 (29.7) | ||
| Yes | 6 | 4 (2.6) | 2 (1.3) | ||
| Lymphovascular space involvement | 0.874 | 1.000 | |||
| No | 146 | 101 (65.2) | 45 (29.0) | ||
| Yes | 9 | 6 (3.9) | 3 (1.9) | ||
| Vital status (at follow-up) | <0.001 | 0.001 | |||
| Alive | 126 | 95 (61.3) | 31 (20.0) | ||
| Dead | 29 | 12 (7.7) | 17 (11.0) | ||
| Recurrence | <0.001 | <0.001 | |||
| No | 137 | 102 (65.8) | 35 (22.6) | ||
| Yes | 18 | 5 (3.2) | 13 (8.4) | ||
GINS2, complex subunit 2; SCC-Ag, squamous cell carcinoma antigen; FIGO, International Federation of Obstetrics and Gynecology.