Table 3. Associations of sex hormones and SHBG with change in mini mental status in linear regression models, separately in men and women.

	β-coefficients (95% CI)
	Total Testosterone	Androstenedione	Free Testosterone	SHBG
Men
5-year follow-up
age-adjusted	0.13 (-0.11; 0.38)	0.35 (-0.20; 0.91)	0.03 (-0.19; 0.26)	0.44 (0.13; 0.74)*
multivariable-adjusted	0.02 (-0.15; 0.20)	0.38 (-0.16; 0.93)	-0.01 (-0.21; 0.19)	0.23 (-0.11; 0.59)
10-year follow-up
age-adjusted	0.01 (-0.20; 0.23)	0.32 (-0.14; 0.80)	0.07 (-0.16; 0.31)	0.10 (-0.26; 0.47)
multivariable-adjusted	0.01 (-0.22; 0.24)	0.27 (-0.21; 0.75)	0.05 (-0.20; 0.30)	0.08 (-0.30; 0.46)
Women
5-year follow-up
age-adjusted	-0.03 (-0.44; 0.36)	-0.17 (-0.48; 0.13)	0.23 (-0.19; 0.66)	-0.31 (-0.74; 0.10)
multivariable-adjusted	-0.10 (-0.49; 0.27)	-0.23 (-0.56; 0.09)	0.23 (-0.17; 0.64)	-0.37 (-0.80; 0.04)
10-year follow-up
age-adjusted	0.06 (-0.37; 0.50)	0.01 (-0.31; 0.35)	0.24 (-0.30; 0.80)	-0.10 (-0.48; 0.26)
multivariable-adjusted	-0.03 (-0.47; 0.41)	0.01 (-0.37; 0.41)	0.14 (-0.45; 0.75)	-0.08 (-0.46; 0.28)

Data are β coefficients and their 95% confidence interval with p < 0.05 marked as *.

The multivariable model was adjusted for age, body mass index, smoking status (three categories), alcohol consumption, physically inactivity, hypertension, baseline mini mental status, and inverse probability weights for drop-out of baseline examination to follow-up. 5-year follow-up change in mini mental status: women N = 176, men N = 177. 10-year follow-up: women N = 184, men N = 182.

SHBG, sex hormone-binding globulin; CI, confidence interval.