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. 2017 May 5;39(6):1421–1427. doi: 10.3892/ijmm.2017.2977

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Ghrelin upregulates uncoupling protein 2 (UCP2) to decrease reactive oxygen species (ROS) generation. (A) Human umbilical vein endothelial cells (HUVECs) were either pre-treated with ghrelin or left untreated, followed by oxidized low-density lipoprotein (oxLDL) stimulation. The cellular ROS level was measured in indicated groups. (B) Western blot analysis for the UCP2 protein level in HUVECs treated with ghrelin. Untreated cells was included as a control. (C) Gradient treatment of HUVECs with ghrelin for the observed the dose-depended upregulation of UCP2 at the protein level. Quantitative experiments were repeated at least 3 times. ^*P<0.05, significant differences between different groups.