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. 2017 May 5;39(6):1421–1427. doi: 10.3892/ijmm.2017.2977

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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siRNA-mediated knockdown of uncoupling protein 2 (UCP2) expression antagonizing ghrelin caused reactive oxygen species (ROS) reduction. (A) Western blot analysis for UCP2 protein level in human umbilical vein endothelial cells (HUVECs) subjected to the indicated treatments. Cells were transfected with siRNA first, and then ghrelin was added to the siRNA-transfected cells. Cells from indicated groups were harvested 24 h later and examined to determine the UCP2 protein level. (B) Quantitative analysis of the ROS level in the indicated groups. (C) The ICAM-1 mRNA level in cells from indicated groups. Experiments were repeated 3 times. ^*P<0.05, significant differences between different groups.