Table V.

The 48 SNPs significantly (P<1.21×10⁻⁶) associated with intracerebral hemorrhage in the exome-wide association study.

Gene	dbSNP	Nucleotide (amino acid) substitutiona	Chromosome: position	MAF (%)	P-value (allele)	Allele OR	95% CI
RECQL	rs146924988	A/G (M1T)	12: 21499569	0.3	8.57×10−103	0.93	0.29–3.00
ATF7IP2	rs13335336	A/G	16: 10465406	17.0	3.91×10−93	1.15	1.00–1.33
SHCBP1	rs11545690	A/C (M60R)	16: 46618297	5.3	3.58×10−76	0.87	0.67–1.13
	rs1405262	T/C	2: 5994808	41.3	6.36×10−70	0.98	0.88–1.10
CAT	rs7943316	A/T	11: 34438925	33.7	1.49×10−53	1.02	0.91–1.15
EXOC6B	rs1517182	C/A	2: 72508184	1.7	8.40×10−52	0.91	0.59–1.41
RNASE10	rs202109789	G/A (G87S)	14: 20510730	0.2	3.52×10−49	1.00	0.31–3.25
GKN2	rs146849599	C/T (V130M)	2: 68946388	2.7	6.04×10−49	0.82	0.57–1.18
IGSF10	rs78090556	G/A (T981M)	3: 151447039	0.2	1.49×10−48	2.57	1.08–6.25
GFM2	rs77099085	G/T (H92N)	5: 74759397	6.4	5.68×10−46	0.93	0.74–1.17
ADRB2	rs1042713	G/A (G16R)	5: 148826877	49.1	4.57×10−36	1.02	0.92–1.15
SPN	rs3764276	C/T	16: 29661882	37.3	5.46×10−36	1.13	1.01–1.26
	rs3135365	T/G	6: 32421478	18.9	4.03×10−32	0.99	0.85–1.14
NAA25	rs12231744	C/T (R876K)	12: 112039251	35.1	1.00×10−30	1.14	1.02–1.28
DNAH11	rs78763603	G/A	7: 21698150	15.3	3.69×10−24	0.99	0.85–1.15
C15orf57	rs3803354	T/C	15: 40564790	8.9	6.29×10−24	0.92	0.76–1.12
BDP1	rs34529158	C/A (P1669Q)	5: 71522303	0.5	3.02×10−23	0.94	0.44–2.04
FLG	rs2184953	G/A (H2194Y)	1: 152308306	36.2	9.10×10−21	0.98	0.88–1.10
	rs563694	T/G	2: 168917561	2.1	1.75×10−20	1.24	0.85–1.79
LOC100996813	rs2453589	G/A	17: 19585538	26.0	8.53×10−19	1.09	0.96–1.23
DPF3	rs757572	T/C	14: 72665321	41.2	2.14×10−17	1.03	0.93–1.16
CCDC18	rs3820059	G/A (S172F)	1: 169421916	7.1	2.24×10−15	0.98	0.79–1.22
	rs11624336	G/A	14: 96727175	14.9	1.56×10−14	0.99	0.84–1.15
AXDND1	rs41267592	C/T (T627M)	1: 179468524	0.3	1.65×10−14	0.62	0.19–1.97
	rs13234712	G/A	7: 119939419	38.8	1.39×10−13	0.98	0.88–1.10
MAPT	rs3785879	C/A	17: 45908270	40.8	8.89×10−12	0.95	0.85–1.06
NLRP13	rs17711239	T/C (N781S)	19: 55907897	9.3	1.57×10−11	1.05	0.87–1.27
AIF1	rs2857697	A/G	6: 31617442	34.1	1.84×10−11	1.19	1.06–1.34
STYK1	rs138533962	G/A (R379C)	12: 10620278	2.0	3.90×10−11	401.7	100.0–995.0
CCDC169	rs9546897	T/C (K120R)	13: 36254100	34.6	3.74×10−10	1.04	0.93–1.16
HMHA1	rs150294461	G/A (G654E)	19: 1080682	1.4	4.63×10−10	1.12	0.69–1.79
TJP3	rs1046268	C/T (T898M)	19: 3750617	29.5	5.56×10−10	1.00	0.88–1.13
PAX5	rs2297105	A/C	9: 37020625	48.3	7.69×10−10	0.98	0.88–1.09
	rs4996815	G/T	13: 105999312	12.6	8.66×10−10	1.03	0.88–1.22
HLA-DPB1	rs9277471	A/G	6: 33085905	43.6	1.55×10−9	1.01	0.90–1.12
SSC4D	rs10227141	C/T (R505G)	7: 76390273	14.4	4.91×10−9	0.94	0.80–1.10
ZCCHC11	rs138145860	A/G (I1270T)	1: 52445800	0.2	1.04×10−8	0.93	0.29–2.99
MOGAT1	rs35959734	G/A (A13T)	2: 222671822	1.2	1.11×10−8	0.82	0.49–1.39
	rs6534076	C/T	4: 118030971	38.4	1.38×10−8	0.96	0.85–1.07
SPATC1L	rs113710653	C/T (E231K)	21: 46161921	1.9	3.75×10−8	3.64	2.43–5.44
LRRC17	rs3800939	A/G (K119E)	7: 102934268	14.0	3.90×10−8	0.97	0.82–1.13
PATE1	rs2114084	A/G (Q47R)	11: 125747715	36.4	2.19×10−7	1.10	0.98–1.23
LY6G6C	rs117894946	G/C (G75A)	6: 31719250	9.5	2.77×10−7	1.06	0.88–1.28
VWA5B1	rs139281890	G/A (R92Q)	1: 20312971	0.2	3.26×10−7	0.44	0.06–3.23
PABPC4	rs4660293	A/G	1: 39562508	15.2	3.99×10−7	1.10	0.95–1.28
ELMO1	rs11984075	A/G	7: 37397251	1.1	5.49×10−7	1.04	0.62–1.74
C2	rs511294	A/C	6: 31921092	0.6	7.29×10−7	1.20	0.63–2.30
	rs2823962	G/A	21: 16673913	32.8	8.40×10−7	0.99	0.88–1.11

Allele frequencies were analyzed with Fisher's exact test.

^aMajor allele/minor allele. SNPs, single nucleotide polymorphisms; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval.