Table VII.
The 12 SNPs significantly (P<1.21×10−6) associated with subarachnoid hemorrhage in the exome-wide association study.
| Gene | dbSNP | Nucleotide (amino acid) substitutiona | Chromosome: position | MAF (%) | P-value (allele) | Allele OR | 95% CI |
|---|---|---|---|---|---|---|---|
| CDL6 | rs2972146 | A/C | 2: 226235982 | 8.7 | 1.28×10−18 | 0.98 | 0.72–1.33 |
| rs3135365 | T/G | 6: 32421478 | 18.9 | 9.71×10−15 | 0.86 | 0.68–1.09 | |
| rs2282978 | T/C | 7: 92635096 | 10.6 | 3.91×10−12 | 1.23 | 0.95–1.59 | |
| rs2639889 | A/G | 16: 61089243 | 32.3 | 4.23×10−11 | 0.88 | 0.72–1.06 | |
| ANKFN1 | rs12449568 | T/C | 17: 56352794 | 42.0 | 3.64×10−10 | 0.92 | 0.77–1.09 |
| CHRDL2 | rs79893604 | G/A (P395L) | 11: 74697229 | 0.8 | 5.70×10−10 | 2.45 | 1.23–4.76 |
| CTNNA3 | rs12256826 | C/T | 10: 66214832 | 13.6 | 8.96×10−10 | 0.83 | 0.63–1.09 |
| SLC4A5 | rs10177833 | A/C | 2: 74230591 | 46.8 | 7.03×10−9 | 0.99 | 0.84–1.18 |
| TEX41 | rs2381683 | A/G | 2: 144981989 | 2.7 | 1.15×10−8 | 1.14 | 0.67–1.91 |
| PYGM | rs589691 | T/C | 11: 64757744 | 42.2 | 1.25×10−8 | 1.06 | 0.89–1.27 |
| rs34429154 | A/C | 1: 4303675 | 40.2 | 1.47×10−8 | 1.04 | 0.87–1.24 | |
| COL17A1 | rs117564807 | C/T (D919N) | 10: 104040357 | 1.1 | 4.83×10−7 | 0.00 | ND |
Allele frequencies were analyzed with Fisher's exact test.
a
Major allele/minor allele. SNPs, single nucleotide polymorphisms; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval; ND, not determined.