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. 2017 Apr 11;6:e22194. doi: 10.7554/eLife.22194

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© 2017, Gaiti et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 7. — (A) Putative adult and larva enhancer-like signatures identified in the 60 metazoan-specific microsyntenic pairs investigated. (B) The cladogram represents known phylogenetic distribution of the Isl2-Scaper microsyntenic gene pair across opisthokonts. The orientation of the arrow corresponds to gene orientation. Isl2-Scaper is not conserved in yeast, Capsaspora, Nematostella and C. elegans. (C) Enhancer elements in the Isl-Scaper microsyntenic gene pair locus in Amphimedon. Scaper and Isl genes (purple) are shown, along with input DNA-normalized coverage of H3K4me3 and H3K4me1 and RNA-seq expression in both adult and larva. Regions of enrichments (high confidence peaks, representing reproducible events across true biological replicates) corresponding to the predicted enhancer-like elements located within the introns of Scaper are highlighted in grey.

DOI: http://dx.doi.org/10.7554/eLife.22194.039

Figure 7—source data 1. 60 microsyntenic units representing functional gene linkages and presence-absence of chromatin states containing typical eumetazoan enhancer histone PTM patterns (‘EnhP’,’ EnhWk’,’ TxEnhA’) (adult only) and/or in silico predicted enhancer-like elements (both larva and adult).
DOI: http://dx.doi.org/10.7554/eLife.22194.040

elife-22194-fig7-data1.xlsx^{(57.7KB, xlsx)}

DOI: 10.7554/eLife.22194.040

Figure 7—figure supplement 1. — (A) Putative adult and larva enhancer-like signatures identified in the 60 metazoan-specific microsyntenic pairs investigated. (B) The cladogram represents known phylogenetic distribution of the Isl2-Scaper microsyntenic gene pair across opisthokonts. The orientation of the arrow corresponds to gene orientation. Isl2-Scaper is not conserved in yeast, Capsaspora, Nematostella and C. elegans. (C) Enhancer elements in the Isl-Scaper microsyntenic gene pair locus in Amphimedon. Scaper and Isl genes (purple) are shown, along with input DNA-normalized coverage of H3K4me3 and H3K4me1 and RNA-seq expression in both adult and larva. Regions of enrichments (high confidence peaks, representing reproducible events across true biological replicates) corresponding to the predicted enhancer-like elements located within the introns of Scaper are highlighted in grey.

DOI: http://dx.doi.org/10.7554/eLife.22194.039

Figure 7—source data 1. 60 microsyntenic units representing functional gene linkages and presence-absence of chromatin states containing typical eumetazoan enhancer histone PTM patterns (‘EnhP’,’ EnhWk’,’ TxEnhA’) (adult only) and/or in silico predicted enhancer-like elements (both larva and adult).
DOI: http://dx.doi.org/10.7554/eLife.22194.040

elife-22194-fig7-data1.xlsx^{(57.7KB, xlsx)}

DOI: 10.7554/eLife.22194.040