Skip to main content
. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Hum Mutat. 2017 Apr 13;38(6):736–744. doi: 10.1002/humu.23218

Figure 1. Pedigree presenting the P2X7 p.T205M, P2X7 p.N361S and P2X4 p.G135S haplotype and protein conservation.

Figure 1

A) Males are represented by squares and females by circles with the proband indicated win an arrow head. Patients diagnosed with MS have black filled symbols with corresponding age at onset of disease when available. Heterozygote carriers for all three mutations (M) and wild type (wt) haplotypes are indicated. B) Conservation of P2X7 and P2X4 variants in orthologs and human paralogs are highlighted in black. Protein homologs were aligned via ClustalO, and RefSeq accession numbers are provided.