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. Author manuscript; available in PMC: 2017 May 12.
Published in final edited form as: Nat Struct Mol Biol. 2016 Aug 29;23(10):941–948. doi: 10.1038/nsmb.3282

Figure 7.

Figure 7

A diagram of substrate signaling in TrmD. This signaling starts with Ado binding to the trefoil-knot, followed by Met binding to assemble the active site, by G37 binding to stabilize tRNA binding, and by methyl transfer at the active site.