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. 2017 May 1;24(5):443–451. doi: 10.5551/jat.RV17001

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2017 Japan Atherosclerosis Society

This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/3.0/

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Fig. 1. — Representative inflammasomes and their components

Several PRRs that recognize distinct DAMPs form the inflammasome complex, which serves as the molecular platform to activate caspase-1. NLRP3 inflammasomes are composed of NLRP3, ASC, and caspase-1. NLRP3 binds ASC via PYD-PYD interaction. Subsequently, ASC binds caspase-1 via CARD–CARD interaction. NLRC4 inflammasomes are composed of NLRC4 and caspase-1, whereas AIM2 inflammasomes are composed of AIM2, ASC, and caspase-1. ATP, adenosine triphosphate; CARD, caspase recruitment domain; DAMPs, damage/danger-associated molecular patterns; HIN, hematopoietic interferon-inducible protein with a 200-amino-acid repeat; LRR, leucine-rich repeats; MSU, monosodium urate; NACHT, found in NAIP, CITA, HET-E ,and TP1; NLR, nucleotide-binding oligomerization domain-like receptor; PRRs, pattern recognition receptors; PYD, pyrin domain.