Table 1. Effects of NLRP3 inflammasome deficiency on progression of atherosclerosis in mice.
| Reference | Model | Diet | Deficient gene | Lesion size | ||
|---|---|---|---|---|---|---|
| Duewell et al. | 2010 | Ref. 8 | Ldlr-/- | WTD (0.15% Cho) | Nlrp3, Asc (BMT) | decrease |
| Menu et al. | 2011 | Ref. 38 | Apoe-/- | HFD (1.25% Cho) | Nlrp3, Asc, Casp1/11 | no change |
| Usui et al. | 2012 | Ref. 9 | Apoe-/- | WTD (0.15% Cho) | Casp1/11 | decrease |
| Gage et al. | 2012 | Ref. 10 | Apoe-/- | HFD (1.5% Cho) | Casp1/11 | decrease |
| Hendrikx et al. | 2015 | Ref. 11 | Ldlr-/- | HFD (0.2% Cho) | Casp1/11 (BMT) | decrease |
Abbreviation: BMT, bone marrow transplant; Cho, cholesterol; HFD, high fat diet; WTD, western diet