Table 1. Comparison of power between traditional risk factors and GRS.
| Baseline characteristics | HR (95% CI) | P value |
|---|---|---|
| Age (per 10-year increment) | 1.86 (1.74 – 1.98) | 2.8 × 10−83 |
| Men | 2.50 (2.28 – 2.74) | 1.4 × 10−84 |
| Body mass index (top vs. bottom quintile) | 1.07 (0.92 – 1.24) | 0.38 |
| Smoking | 1.81 (1.66 – 1.98) | 1.1 × 10−38 |
| Hypertension | 1.69 (1.53 – 1.86) | 1.6 × 10−25 |
| Prevalent diabetes mellitus | 2.43 (2.12 – 2.78) | 4.0 × 10−37 |
| Apolipoprotein B (top vs. bottom quintile) | 2.39 (2.03 – 2.82) | 9.0 × 10−26 |
| Apolipoprotein A1 (bottom vs. top quintile) | 1.87 (1.61 – 2.18) | 5.0 × 10−16 |
| Self-reported family history | 1.41 (1.29 – 1.53) | 2.9 × 10−15 |
| GRS (top vs. bottom quintile) | 1.85 (1.61 – 2.12) | 1.2 × 10−18 |
HR: hazard ratio, GRS: genetic risk score