Table 1.
Baseline features of 317 participants in the CRC-SCA cohort.
| SCA 1 |
p-value | SCA 2 |
p-value | SCA 3 |
p-value | SCA 6 |
p-value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gait-onset | Non-gait-onset | Gait-onset | Non-gait-onset | Gait-onset | Non-gait-onset | Gait-onset | Non-gait-onset | |||||
| n (%) | 48 (92.3) | 4 (7.7) | 60 (87.0) | 9 (13.0) | 112 (87.5) | 16 (12.5) | 57 (83.8) | 11 (16.2) | 0.585a | |||
| Age at first visit (yrs) | 50.9 ± 12.9 | 46.3 ± 15.7 | 0.493b | 52.4 ± 12.2 | 42.9 ± 17.3 | 0.144b | 50.6 ± 12.3 | 55.9 ± 11.8 | 0.105b | 66.5 ± 9.7 | 60.2 ± 14.5 | 0.190b |
| Age of onset (yrs) | 40.4 ± 11.6 | 37.8 ± 14.6 | 0.671b | 37.2 ± 11.4 | 28.2 ± 14.8 | 0.039b | 38.0 ± 11.5 | 37.8 ± 13.5 | 0.932b | 52.2 ± 9.8 Median = 52.0 |
49.4 ± 14.2 Median = 48.0 |
0.554c |
| Disease duration (yrs) | 10.6 ± 7.2 Median = 8.0 |
8.5 ± 7.9 Median = 6.0 |
0.324c | 15.3 ± 8.6 Median = 14.0 |
14.7 ± 9.3 Median = 14.0 |
0.789c | 12.6 ± 7.4 Median = 12.0 |
18.2 ± 9.5 Median = 19.5 |
0.019c | 14.4 ± 11.0 Median = 11.0 |
10.8 ± 4.9 Median = 9.0 |
0.605c |
| Sex, M:W | 28:20 | 1:3 | 0.310a | 32:28 | 7:2 | 0.281a | 56:56 | 10:6 | 0.428a | 30:27 | 8:3 | 0.323a |
| CAG repeat | 46.0 ± 4.6 | 48.0 ± 2.5 | 0.391b | 39.4 ± 2.5 Median = 39.0 |
39.6 ± 7.6 Median = 40.0 |
0.243c | 71.0 ± 4.0 Median = 71.0 |
70.3 ± 4.1 Median = 71.0 | 0.432c | 22.3 ± 0.8 Median = 22.0 |
22.5 ± 1.6 Median = 22.0 |
0.626c |
| Baseline SARA score | 14.1 ± 8.3 | 19.6 ± 6.8 | 0.198b | 16.7 ± 7.6 | 16.8 ± 6.1 | 0.965b | 15.2 ± 9.2 Median = 14.0 |
14.8 ± 6.9 Median = 14.5 |
0.925c | 13.9 ± 7.3 | 15.0 ± 8.5 | 0.674b |
| Baseline UHDRS-IV score | 18.9 ± 6.4 Median = 20.0 |
15.0 ± 4.8 Median = 15.0 |
0.149c | 18.5 ± 6.2 Median = 20.0 |
19.0 ± 5.0 Median = 19.0 |
0.978c | 17.2 ± 7.0 Median = 18.0 |
17.0 ± 6.3 Median = 19.0 |
0.694c | 18.6 ± 5.8 Median = 20.0 |
18.6 ± 5.9 Median = 21.0 |
0.861c |
| Baseline PHQ-9 score | 5.7 ± 6.4 Median = 3.0 |
13.0 ± 8.7 Median = 12.5 |
0.050c | 5.4 ± 5.6 Median = 3.5 |
4.1 ± 3.7 Median = 3.0 |
0.838c | 7.5 ± 6.0 Median = 6.0 |
6.1 ± 3.6 Median = 5.5 |
0.573c | 6.6 ± 6.0 Median = 5.0 |
5.6 ± 5.8 Median = 5.0 |
0.627c |
| Baseline EQ-5D score | 3.0 ± 1.7 Median = 5.0 |
4.8 ± 1.5 Median = 3.0 |
0.065c | 3.1 ± 1.7 Median = 3.0 |
2.0 ± 1.2 Median = 2.0 |
0.064c | 3.5 ± 2.1 Median = 3.0 |
3.8 ± 1.4 Median = 4.0 |
0.358c | 3.1 ± 1.7 Median = 3.0 |
2.6 ± 1.8 Median = 2.5 |
0.429c |
a
Chi-square test
b
Two-independent samples t-test
c
Two-independent samples Mann-Whitney U test
Abbreviations: CRC-SCA = the Clinical Research Consortium for Spinocerebellar Ataxias; SARA = Scale for Assessment and Rating of Ataxia; UHDRS = Unified Huntington's Disease Rating Scale; PHQ-9 = Patient Health Questionnaire; EQ-5D = quality of life measurement from 5 domains.
Values represent mean ± standard deviation or number, and for variables with non-normal distribution, the median is reported as well.
Values in bold are statistically significant.