Table 3.
Regression coefficients of SARA scorea |
||||
---|---|---|---|---|
SCA1 | SCA2 | SCA3 | SCA6 | |
Age of first visit (yrs) | 0.26 | 0.30**** | 0.55**** | 0.35**** |
Sexb | 2.99 | −1.68 | −0.19 | −0.14 |
CAG repeat | 0.56 | 0.89* | 1.30**** | 2.24**** |
Initial symptomc | −5.33 | −2.03 | 2.20 | −3.50 |
Visit time | 2.11**** | 0.70 | 0.37 | −0.00 |
Initial symptom × Visit time | −1.03** | 0.03 | −0.02 | 1.60**** |
Regression coefficients UHDRS-IV scorea |
||||
---|---|---|---|---|
SCA1 | SCA2 | SCA3 | SCA6 | |
Age of first visit (yrs) | −0.17 | −0.14* | −0.55**** | −0.23*** |
Sexb | −2.41 | 0.31 | 0.08 | 0.15 |
CAG repeat | −0.34 | −0.59 | −1.36**** | −1.43 |
Initial symptomc | 3.14 | 1.27 | −1.27 | 1.52 |
Visit time | −0.68 | 0.96*** | −0.60 | −0.21** |
Initial symptom X Visit time | 0.12 | −0.83* | −0.57 | −0.36 |
Regression coefficients of PHQ-9 scorea |
||||
---|---|---|---|---|
SCA1 | SCA2 | SCA3 | SCA6 | |
Age of first visit (yrs) | 0.04 | 0.00 | 0.18* | −0.05 |
Sexb | −0.05 | −1.41 | 1.91 | −0.88 |
CAG repeat | 0.19 | −0.07 | 0.35 | −0.87 |
Initial symptomc | −8.35* | 2.63 | 1.52 | 0.51 |
Visit time | −1.07 | 2.06 | 0.64 | −0.80 |
Initial symptom X Visit time | 1.18 | −1.81 | −0.05 | 0.75 |
Regression coefficients of EQ-5D scorea |
||||
---|---|---|---|---|
SCA1 | SCA2 | SCA3 | SCA6 | |
Age of first visit (yrs) | 0.04 | 0.03* | 0.08**** | −0.03 |
Sexb | −0.13 | −0.30 | 0.04 | 0.23 |
CAG repeat | 0.13 | 0.11 | 0.20*** | −0.10 |
Initial symptomc | −1.64* | 0.54 | −0.20 | 0.32 |
Visit time | −0.17 | −0.33 | −0.03 | −0.04 |
Initial symptom X Visit time | 0.29 | 0.22 | 0.25 | 0.19 |
All regression coefficients were calculated in GEE model, adjusting for age of first visit, sex, CAG repeat, initial symptom, and initial symptom*visit time.
Man = 0, Woman = 1
Non-gait-onset = 0, Gait-onset = 1
<0.05
<0.01
<0.005
<0.001
Abbreviations: SARA = Scale for Assessment and Rating of Ataxia; UHDRS = Unified Huntington's Disease Rating Scale; PHQ-9 = Patient Health Questionnaire; EQ-5D = quality of life measurement from 5 domains; GEE = Generalized Estimating Equation; SCA = Spinocerebellar Ataxia.