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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Pharmacol Ther. 2017 Feb 7;174:43–54. doi: 10.1016/j.pharmthera.2017.02.017

Fig. 2.

Fig. 2

F4/80 positive cells are located throughout the marrow and intimately associated with bone surfaces. Tibiae from 22-week old C57BL/6 mice were paraffin embedded, sectioned and immunohistochemical stained (brown) for F4/80 and counterstained with hematoxylin (blue) as previously described (Cho, et al., 2014). Macrophages are located adjacent to bone surfaces (black arrowheads) and throughout the marrow space. F4/80+ cells are also associated with blood vessels (BV) and support hematopoiesis (red arrowheads).