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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Pharmacol Ther. 2017 Feb 7;174:43–54. doi: 10.1016/j.pharmthera.2017.02.017

Table 1.

Bone macrophage markers and roles.

Macrophage Current Known Markers Roles References
Erythroblastic island macrophages (EIM) CD11b
F4/80
CD169
VCAM-1
ER-HR3
Ly6G
TRAP (neg)		 Support erythropoiesis (Chow, et al., 2013; Jacobsen, et al., 2014)
HSC niche macrophages CD11b
F4/80
CD169
VCAM-1
CD234
Ly6G (neg)
TRAP (neg)		 Support and regulate HSC niche self-renewal and cycling (Chow, et al., 2011; Christopher, et al., 2011; Winkler, et al., 2012; Winkler, et al., 2010)
Osteal macrophages F4/80
CD115
CD68
Mac-3
TRAP (neg)		 Support bone homeostasis Support fracture healing (Alexander, et al., 2011; Chang, et al., 2008)
Osteoclasts F4/80 (neg)
TRAP (pos)
Cathepsin K
 Bone resorption (Holtrop & King, 1977; Vaananen, et al., 2000)
Calcitonin Receptor Efferocytosis (Harre, et al., 2012)