Table 2.
Marginal structural models evaluating odds ratios for the association of PTSD severity and remission with incident CVD
| Model 1* | Model 2** | |||||||
|---|---|---|---|---|---|---|---|---|
| Obs (cases) |
OR | 95% CI | Obs (cases) |
OR | 95% CI | |||
| No trauma (ref) | 125,283 (100) |
1.00 | (Reference) | 109,945 (95) |
1.00 | (Reference) | ||
| Trauma no PTSD | 249,370 (295) |
1.30 | 1.03 | 1.65 | 224,174 (291) |
1.31 | 0.97 | 1.78 |
| Mild ongoing PTSD symptoms |
35,471 (40) |
1.10 | 0.75 | 1.62 | 32,342 (40) |
1.01 | 0.64 | 1.60 |
| Moderate ongoing PTSD symptoms |
27,485 (39) |
1.41 | 0.95 | 2.09 | 25,145 (38) |
1.21 | 0.74 | 1.97 |
| Severe ongoing PTSD symptoms |
19,631 (35) |
1.69 | 1.08 | 2.63 | 17,932 (35) |
2.28 | 1.30 | 4.02 |
| Remitted mild PTSD symptoms |
25,024 (19) |
0.70 | 0.41 | 1.21 | 23,418 (19) |
0.70 | 0.39 | 1.25 |
| Remitted moderate/severe PTSD symptoms |
14,880 (24) |
0.86 | 0.51 | 1.46 | 14,114 (24) |
1.07 | 0.55 | 2.08 |
Abbreviations: CI=confidence interval; CVD=cardiovascular disease;Obs=observations; OR=odds ratio; PTSD=posttraumatic stress disorder
Women contributed an observation each time they completed a questionnaire cycle; 49,859 women contributed these 497,144 observations. Models were adjusted for the following confounders: baseline age, race/ethnicity (minority vs not minority status), parental education, home ownership, maternal history of MI or stroke, paternal history of MI or stroke, age, and neighborhood income.
Model 2 included 49,826 women who contributed 447,070 observations over the follow up period and adjusted for all potential confounders present in Model 1 as well as physical activity, alcohol, smoking, and diet