Table 1.
Number of test compound classified as inhibitors (IC50 < 80 μM), weak inhibitors (IC50 > 80 μM), inactive molecules and stimulators within the five scaffolds in this study. The number in parenthesis respond to the combined number of test compounds from this study and Wissel et al 2015.
| Scaffold 1 | Scaffold 2 | Scaffold 3 | Scaffold 4 | Scaffold 5 | Total | |
|---|---|---|---|---|---|---|
| Inhibitor | 5 (19) | 19(26) | 5 (10) | 2 (4) | 7 (8) | 38 (67) |
| Weak inhib. | 6 (10) | 8 (17) | 1 (4) | 7 (11) | 18 (18) | 40 (60) |
| Inactive | 0 (1) | 2 (9) | 1 (3) | 13 (15) | 17 (17) | 33 (45) |
| Stimulator | 0 (0) | 0 (0) | 0 (0) | 2 (2) | 1 (1) | 3 (3) |
|
| ||||||
| Total | 11(30) | 29 (52) | 7 (17) | 24 (32) | 43(44) | 114 (175) |