Table 4.

Scaffold 3.

#	-R1	-R2	-R3	IC50 (95% CI), μM	Hill slope (95% CI)
3aa		-Br	-H	58 (37 – 90)	−1.3 (−1.9, −0.6)
3ab			-H	inhibitorb
3ac			-H	8 (4–16)	−0,9 (−1.4, −0.5)
3ad			-H	23 (19–28)	n.dc
3ae		-H		inactivea
3af			-H	inhibitorb
3ag		-H	-H	weak inhibitora

^amodulatory effect estimated from three concentrations only;

^b4-parameter logistic model curve could not be fitted.

^cHill coefficient could not be calculated with significant accuracy (within 3 units).