. Author manuscript; available in PMC: 2018 May 30.

Published in final edited form as: Eur J Pharm Sci. 2017 Feb 7;103:60–69. doi: 10.1016/j.ejps.2017.02.005

Table 7.

Scaffold 5B.

	R₁	IC₅₀ (95% CI), μM	Hill slope (95% CI)
5bg	-H	weak inhibitor^a
5bh	-H	136 (83 – 223)	−0.8 (−1.2 ; −0.5)
5bi	4-CH₃	inactive^a
5bj	4-CH₃	inactive^a
5bk	4-CH₃	inactive^a
5bl	4-CH₃	inactive^a
5bm	4-OCH₃	inactive^a
5bn	4-NH₂	inactive^a
5bo		inactive
5bp		weak inhibitor^a
5bq	2-CH₃; 5-NO₂	inactive

modulatory effect estimated from three concentrations only;

4-parameter logistic model curve could not be fitted.

Hill coefficient could not be calculated with significant accuracy (within 3 units).