Figure 5. Cdc50 influences sensitivity to cinnamycin and miltefosine.
Deletion of CDC50 causes increased sensitivity to the PE-binding antifungal peptide cinnamycin (Ro09-0198) (A) and the PC-binding miltefosine (B). The sensitivities of the strains to the drugs are shown at a range of concentrations. After 72 h of incubation at 30°C, optical densities (OD600) were measured and the values of cultures incubated without the peptide were normalized to 100% growth. Three replicates of the experiment were performed.