Figure 8. Loss of CDC50 influences growth at acidic and alkaline pH, and sensitivity to salt stress.
(A) Tenfold serial dilutions of each strain were spotted onto buffered YPD, and the plates were incubated at 30°C for 2 days before being photographed. (B) Tenfold serial dilutions of the strains were spotted onto solid YPD without or with 1.2 M NaCl, 1.5 M KCl, 1.5 M sorbitol, or 100 mM LiCl. The plates were incubated at 30°C for the following times: sorbitol, 3 days; KCl, 5 days; NaCl, 5 days; LiCl, 10 days. (C) Loss of CDC50 did not influence the localization of RIM101-GFP, but deletion of the genes encoding ESCRT complex proteins or Rim101 regulatory components caused mis-localization. Bar = 10 µm.