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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Neurochem. 2017 May 3;141(5):708–720. doi: 10.1111/jnc.14025

Figure 5.

Figure 5

Dimercaprol protected PC-12 cells from acrolein-mediated plasma membrane damage and cell death based on LDH assay. PC-12 cells were exposed to 100 μM acrolein for 4 hrs. Some of them were treated with additional different concentrations of dimercaprol after 15 min of acrolein exposure. The protection effects of dimercaprol were examined by LDH releasing assay. The percentage of LDH release was normalized to 0% for the control group (no acrolein or dimercaprol). The LDH release for other groups was expressed as the percentages of LDH level when all LDH was released from cells. Treatment with dimercaprol significantly reduced acrolein-mediated cell membrane damage (p<0.05 or p<0.01, ANOVA). All data were expressed as mean ± SEM, n=5.