Table 2.
Summary of previously reported cases of CTAT
| References | Age/gender | Anatomic location | IHC | Metastasis status | Treatment | Outcome |
|---|---|---|---|---|---|---|
| Bell et al. [3] | 58 M | Base of tongue | (+): CK20, CDX2, beta-catenin, CK7 (focal), MLH1, MSH2, MSH6, PMS2 | Positive—1 lymph node | Surgery | No evidence of recurrence (13 months) |
| 58 M | Base of tongue | (+): CK20, CDX2, beta-catenin, MLH1, MSH2, MSH6, PMS2 | Positive—bilateral lung nodules, multiple lymph nodes | Chemotherapy + surgery | No evidence of recurrence (11 months) | |
| (−): CK7 | ||||||
| Slova et al. [4] | 49 M | Base of tongue | (+): AE1/3, CK20, CK7, CAM5.2, CDX2, villin, EMA, p16, CEA | Positive—4/64 lymph nodes | Surgery + adjuvant radiation | |
| McDaniel et al. [5] | 60 M | Anterior tongue | (+): CDX2, CK7, CK20 | Positive—bilateral cervical lymph nodes | Surgery + adjuvant chemotherapy and radiation | Recurrence of disease as lung metastases (14 months postoperative); DOD 5 years postoperation |
| (−): TTF-1 | ||||||
| Smith et al. (present case) | 53 F | Anterior (Oral) tongue | (+): AE1/3, CK20, CDX2, SATB2, beta-catenin, MLH1, MSH2, MSH6, PMS2 | Negative | Surgery + adjuvant radiation | No evidence of recurrence or metastasis (8 months) |
| (−): CK7 |