Table 1.
Clinical and pathologic features stratified by PD-L1 expression. Positive PD-L1 expression is defined as 1% or more tumor cells with membranous PD-L1 staining
| Total N = 56 | PD-L1− N = 20 |
PD-L1+ N = 36 |
P | |
|---|---|---|---|---|
| Mean age (year, [median, range]) | 48.7 (48.5, 19–71) | 48.9 (49.0, 19–67) | 48.6 (48.0, 24–71) | 0.995 |
| Sex (n, [%]) | ||||
| Female | 13 (23) | 4 (20) | 9 (25) | 0.752 |
| Male | 43 (77) | 16 (80) | 27 (75) | |
| pT (n, [%]) | ||||
| T1 | 17 (30) | 8 (40) | 9 (25) | 0.541 |
| T2 | 16 (29) | 4 (20) | 12 (33) | |
| T3 | 12 (21) | 5 (25) | 7 (19) | |
| T4 | 11 (20) | 3 (15) | 8 (22) | |
| pN (n, [%]) | ||||
| pN0 | 22 (39) | 6 (30) | 16 (44) | 0.476 |
| pN1 | 27 (48) | 11 (55) | 16 (44) | |
| pN2 | 4 (7) | 1 (5) | 3 (8) | |
| pN3 | 3 (5) | 2 (10) | 1 (3) | |
| pM (n, [%]) | ||||
| pM0 | 49 (88) | 17 (85) | 32 (89) | 0.691 |
| pM1 | 7 (12) | 3 (15) | 4 (11) | |
| Stage (n, [%]) | ||||
| Stage I | 11 (20) | 3 (15) | 8 (22) | 0.879 |
| Stage II | 16 (29) | 7 (35) | 9 (25) | |
| Stage III | 12 (21) | 4 (20) | 8 (22) | |
| Stage IV | 17 (30) | 6 (30) | 11 (31) | |
| Total follow-up time (month, mean [median, range]) | 51.3 (51.5, 14–88) | 47.5 (49.5, 14–71) | 53.5 (52.5, 31–88) | 0.297 |
| Treatment (n, [%]) | ||||
| Radiation | 2 (4) | 1 (5) | 1 (3) | 1.000 |
| Chemotherapy and radiation | 54 (96) | 19 (95) | 35 (97) | |
| Tobacco use (n, [%])a | N = 46 | N = 18 | N = 28 | |
| Non-smoker | 32 (70) | 9 (50) | 23 (82) | 0.047 |
| Smoker | 14 (30) | 9 (50) | 5 (18) | |
| Alcohol use (n, [%])a | N = 46 | N = 18 | N = 28 | |
| Non-drinker | 30 (65) | 10 (56) | 20 (71) | 0.215 |
| Drinker | 16 (35) | 8 (44) | 8 (29) | |
aEither tobacco or alcohol usage was unknown for 10 patients