Table 1.

Advantages of using BMCT

Advantages	Detail	References
Various administration routes	Intravenous	[4–18]
	Intraperitoneal	[19–23]
	Intratumoral	[19, 24–27]
	Oral	[17, 28, 29]
Broad tumor-targeting ability	Colon	[7, 9, 10, 14, 19, 24, 30, 31]
	Fibrosarcoma	[17]
	Bladder	[13]
	Liver	[6, 7, 15, 30]
	Pancreas	[8, 21]
	Lung	[14, 15]
	Melanoma	[18, 20, 22, 27, 28, 31, 32]
	Breast	[4, 11, 12, 16, 23, 25, 31]
	Prostate	[20, 26]
Flexibility of delivery	Protein derived from eukaryotes	[5, 12, 20, 29]
	Protein derived from prokaryotes	[7, 11, 30, 31]
	Enzyme-prodrug	[4, 13]
	DNA	[18, 19, 25]
	siRNA, shRNA	[9, 26, 28]
Facilitating host’s immune responses	TAM reduction	[16]
	Antigen delivery	[17, 23, 33]
	Upregulation of gap junction	[27]
	Shift from immune suppressive to immunogenic	[22, 24]
Noninvasive monitoring	Luminescence	[6, 7, 14, 30, 31, 34–37]
	Fluorescence	[8]
	MRI	[38]
	PET	[39]
Can be combined with other therapies	Chemotherapy	[5, 13, 15, 32]
	Radiation	[12, 21, 31]
	Viral therapy	[14]