Table 6.

Recognized indications of tranexamic acid in pediatrics (expert opinion)

Excessive fibrinolysis (e. g. liver transplantation, medication induced)

Adjuvant as hemostatic agent, in hemophilia and von Willebrand disease (e. g. dentistry, not in renal bleeding!)

Mucosal bleeding (topicala, oral, intravenous), exception: bleeding of the upper urinary tract

Primary and adjuvant in hereditary thrombopathies/thrombopenia [102, 103]

PAI 1 deficiency, α2-plasmin inhibitor deficiency, hereditary telangiectasia

Adjuvant in: acquired thrombocytopenia cardiac surgery bypass surgery

^aTopical use: TXA (solution for injection) is locally applied without dilution or diluted with NaCl 0.9%; when applied in the mouth the swallowed amount should be added to the total dosage. The topical application is not included in the SmPC