Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Dec 8;91(6):2283–2294. doi: 10.1007/s00204-016-1905-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Fig. 4 — MALDI imaging mass spectrometry analysis of neuropeptides in L-DOPA-induced dyskinesia. a I Unilateral 6-OHDA injection leads to dopamine depletion (illustrated by tyrosine hydroxylase immunostaining*). L-DOPA therapy results in two distinct groups with low and high dyskinesia. II Striatal and III substantia nigra sections are analyzed by MALDI IMS and regions of interest (ROI) are assigned for spectral data extraction. b Dynorphin peptides, I dynorphin B and II alpha neoendorphin were significantly increased in the dorsolateral striatum of high (HD) compared to low dyskinetic (LD) animals and lesion controls (LC). III Similarly, endogenous dynorphin peptides (e.g., alpha neoendorphin) were increased in the substantia nigra reticulata on the parkinsonian side following L-DOPA treatment. c The results are verified by spectral analysis and nonparametric ANOVA and post hoc statistics. Scalebar 2 mm. Adapted from: Ljungdahl et al. PLoS One. 2011; 6(9) and Hanrieder et al. Mol Cell Proteomics. 2011; 10(10)