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. 2017 Apr 3;136(6):727–741. doi: 10.1007/s00439-017-1786-7

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Manhattan plot of exact mid p values for Hardy–Weinberg equilibrium of the JPT sample. The horizontal line corresponds to the Bonferroni significance threshold ( $- l o g_{10} (0.05 / 12133408) = 8.4$ , using only polymorphic autosomal variants)