Table 3.
The pharmacological parameters of phenylephrine and acetylcholine dose-response curves of all experimental groups after 4 weeks of treatment with vehicle or Crataegus azarolus subspecies aronia extract
| Phenylephrine | Acetylcholine | |||
|---|---|---|---|---|
| Emax (% contraction) | EC50 -Log (M) | Emax (%relaxation) | IC50 -Log (M) | |
| Sham-V | 100±0.00 | -7.5±0.75 | 85.9±4.1 | -7.5±0.20 |
| RAC-V | 160.9±6.1* | -8.3±0.32** | 70.3±4.9* | -5.3±0.07** |
| RACE-5 | 112.9±10.2∆ | -7.9±0.52∆ | 84.4±3.4∆ | -5.9±0.01∆ |
| RACE-10 | 139.8±7.1∆ | -7.2±0.21∆∆ | 79.7±2.3∆ | -6.1±0.11∆∆ |
| RACE-20 | 135.6±4.7∆ | -7.2±0.32∆∆ | 85.3±4.7∆ | -6.2±0.19∆∆ |
| RACE-30 | 136.3±7.1∆ | -7.2±0.14∆∆ | 83.5±5.1∆ | -6.2±0.45∆∆ |
The values (n=6-8) are presented as mean±SEM. Sham-V: Sham-operated group receiving vehicle (distilled water; 0.5 ml/day), RAC-V: Left renal artery-clipped group receiving the vehicle, RAC-E5: Left renal artery-clipped group receiving 5 mg/kg/day Crataegus azarolus subspecies aronia extract, RAC-E10: Left renal artery-clipped group receiving the extract at 10 mg/kg/day, RAC-E20: Left renal artery-clipped group receiving the extract at 20 mg/kg/day, RAC-E30: Left renal artery-clipped group receiving the extract at 30 mg/kg/day. *,**Significant (*P=0.01, **P=0.001) difference from Sham-V group; Δ,ΔΔSignificant (ΔP=0.01, ΔΔP=0.045) difference from RAC-V group