Table 1.
Overall sensitivity of the urine LAM using random versus EMU samples, and stratified by diagnostic category and preceding anti-TB treatment
| Sensitivity 95% (CI) |
Manufacturer recommended LF-LAM positive cut point (grade 2) | P-value | |
|---|---|---|---|
| Random Urine %, 95% CI, n/N |
Early Morn. Urine %, 95% CI, n/N |
||
| Definite- TB only | 12 (5–24) (5/41) |
39 (26–54) (16/41) |
0.005 |
| Probable TB only | 9.6 (5–17) 8/82 |
24 (16–34) 20/82 |
0.001 |
| Definite and Probable TB combined | 10 (6–17) (13/123) |
30 (22–38) (36/123) |
<0.001 |
| No TB Rx prior | 11 (4–28) (3/27) |
31 (17–50) (8/26) |
0.05 |
| TB Rx prior <7 days |
10 (2–40) (1/10) |
56 (27–81) (5/9) |
0.04 |
| No TB Rx prior | 15 (8–27) (8/52 |
25 (15–38) (13/52) |
0.1 |
| TB Rx prior < 7 day |
0 (0–11) (0/30) |
23 (12–41) (7/30) |
0.003 |
| No TB Rx prior | 14 (8–23) (11/79) |
30 (18–38) (21/78) |
0.03 |
| TB Rx prior < 7 days |
2 (0–12) (1/42) |
30 (18–45) (12/40) |
<0.001 |