Table 3.
Allele and genotype frequencies in AITD patients and controls
| GENE | SNP | Alleles | Con (%) | GD (%) | P | Adjusted OR (95%CI) | HT (%) | P | Adjusted OR (95%CI) |
|---|---|---|---|---|---|---|---|---|---|
| Sepp1 | rs6865453 | A | 1338 (74.5) | 983 (72.8) | 0.307 | 0.918 (0.779–1.081) | 514 (74.1) | 0.813 | 0.975 (0.791–1.201) |
| C | 458 (25.5) | 367 (27.2) | 180 (25.9) | ||||||
| AA | 491 (54.7) | 354 (52.4) | 0.403 | 0.918 (0.751–1.122) | 184 (53.03) | 0.605 | 0.936 (0.727–1.203) | ||
| AC + CC | 407 (45.3) | 321 (47.6) | 163 (47.0) | ||||||
| GPX4 | rs713041 | C | 1031 (57.4) | 751 (55.6) | 0.329 | 0.932 (0.809–1.073) | 390 (56.2) | 0.739 | 0.970 (0.810–1.160) |
| T | 765 (42.6) | 599 (44.37) | 304 (43.8) | ||||||
| CC | 300 (33.4) | 213 (31.6) | 0.418 | 0.915 (0.739–1.133) | 105 (30.3) | 0.370 | 0.883 (0.674–1.158) | ||
| CT + TT | 598 (66.6) | 462 (68.5) | 242 (69.7) | ||||||
| rs2074451 | G | 1004 (56.0) | 738 (55.2) | 0.698 | 0.972 (0.843–1.120) | 375 (54.66) | 0.713 | 0.966 (0.806–1.158) | |
| T | 790 (44.0) | 598 (44.8) | 311 (45.3) | ||||||
| GG | 292 (31.4) | 207 (31.0) | 0.833 | 0.977 (0.786–1.213) | 96 (27.99) | 0.343 | 0.874 (0.662–1.154) | ||
| GT + TT | 615 (68.6) | 451 (69.0) | 247 (72.0) | ||||||
| rs3746165 | C | 1019 (56.7) | 738 (54. 7) | 0.259 | 0.921 (0.798)–1.062) | 384 (55.33) | 0.625 | 0.955 (0.796–1.146) | |
| T | 777 (43.3) | 612 (45.3) | 310 (44.7) | ||||||
| CC | 287 (32.0) | 203 (30.1) | 0.416 | 0.914 (0.736–1.135) | 98 (28.24) | 0.272 | 0.857 (0.650–1.129) | ||
| CT + TT | 611 (68.0) | 472 (70.0) | 249 (71.8) | ||||||
| SEPS1 | rs28665122 | C | 1688 (93.5) | 1267 (94.4) | 0.297 | 1.168 (0.872–1.566) | 668 (95.16) | 0.148 | 1.325 (0.904–1.943) |
| T | 118 (6.5) | 75 (5.6) | 34 (4.8) | ||||||
| CC | 793 (87.8) | 598 (89.1) | 0.432 | 1.134 (0.828–1.554) | 320 (91.2) | 0.104 | 1.420 (0.930–21.67) | ||
| CT + TT | 110 (12.2) | 73 (10.9) | 31 (8.8) | ||||||
| rs7178239 | G | 802 (45.6) | 620 (46.9) | 0.496 | 1.051 (0.910–1.214) | 291 (42.4) | 0.167 | 0.881 (0.735–1.054) | |
| C | 958 (54.4) | 702 (53.1) | 395 (57.6) | ||||||
| GG | 180 (20.5) | 145 (21.9) | 0.514 | 1.085 (0.848–1.389) | 63 (18.4) | 0.370 | 0.863 (0.625–1.190) | ||
| CG + CC | 700 (79.6) | 516 (78.1) | 280 (81.6) |